睡眠剥夺可以改变大脑皮质的兴奋性,造成皮质兴奋和抑制失衡现象。对于几乎所有类型的癫,睡眠剥夺是一种强有力的疒间性发作激活剂,可有效地激活全面性和部分性发作间期放电,特别是对特发性全面性癫。现从神经递质和神经肽机制探讨睡眠剥夺对癫发作的影响机制。 Sleep deprivation can change the excitability of the cerebral cortex, resulting in cortical excitement and inhibition of imbalances. For almost all types of epilepsy, sleep deprivation is a potent intercostal seizure activator that effectively activates both generalized and partial interictal discharges, especially for idiopathic generalized epilepsy. The mechanisms of sleep deprivation on epileptic seizures are investigated by neurotransmitters and neuropeptide mechanisms.