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作者为研究适时给克罗米酚对激素水平、卵泡发育，生殖器官和妊娠率的影响。于1997年对23例原因不明至少1年以上不孕的病员进行研究，月经周期25～35天，周期第一天超声检查除外卵巢囊肿；输卵管通畅，黄体中期孕酮值＞10ng／ml，配偶按WHO标准精液正常。分为研究组及对照组。研究组在周期第l～5天给克罗米酚（CC）l（）Omg，第5～9天给安慰剂，对照组则于周期第l～5天给安慰剂，第5～9天给CC］00mg。于周期第1，5，9天分别做B超，血FSH、LH、E。检查，当主卵泡直径达到16。m时每日检查I3超，主卵泡直径达Zlmm时肌肉注射hCGI000OU以诱导排卵，其后24～40h行一次宫腔内人工授精（IUI），授精后14天作血清妊娠试验。23例共行45个周期CC和IUI，平均年龄31．3岁（25．9～39．6），不孕症时间平均36个月（12一sl个月），研究组于周期第5天FSH为6．7mlU／ml，LH7．ITTllU／ml，E2103．ZPg／ml水平均较对照组明显升高。对照组促性腺激素峰值发生在周期第9天，到hCG注射时FSH，LH，E；均无明显差别，两组中观察到卵泡生长无明显区别，研究组卵泡发育迅速些，第9天时有较多卵泡直径＞14mm，但在hCG注射时排卵前卵泡数之明显差别。两组子宫内膜厚度及第5天后子宫动脉搏动指数均无明显差别，但研究组hCG注射时血管?
The authors investigated the effect of clomiphene on hormone levels, follicular development, reproductive organs and pregnancy rates in a timely manner. In 1997, 23 patients with at least one unexplained unexplained disease were studied. The menstrual cycle was 25-35 days. The ovarian cyst was excluded on the first day of the ultrasound examination. The tubal patency, progesterone level in the mid luteal phase was> 10 ng / ml, Sperm according to WHO standard normal. Divided into study group and control group. In the study group, clomiphene citrate (CC) was administered on days 1 to 5, placebo on days 5 to 9, and placebo on days 1 to 5 of the cycle. Day 5 to day 9 Give CC] 00mg. On the 1st, 5th and 9th days of the cycle, B ultrasound, blood FSH, LH and E were done respectively. Check, when the main follicle diameter reaches 16. m when the daily inspection of I3 super, the main follicle diameter of Zlmm intramuscular injection of hCGI000OU to induce ovulation, followed by a line of intrauterine insemination (IUI) 24 ~ 40h, 14 days after fertilization serum pregnancy test. Twenty-three patients had CC and IUI for 45 cycles, mean age was 31.3 years (range, 25.9-39.6), infertility time was 36 months (12- sl months), and the study group was on the 5th day FSH was 6.7 mlU / ml, LH7. ITTllU / ml, E2103. ZPg / ml levels were significantly higher than the control group. In the control group, the peak of gonadotrophin occurred on the 9th day of the cycle. There was no significant difference in FSH, LH and E at the time of hCG injection. There was no significant difference in the follicle growth between the two groups. In the study group, More follicles> 14 mm in diameter, but significant differences in the number of preovulatory follicles during hCG injection. There was no significant difference between the two groups in endometrial thickness and uterine arterial pulse index after 5 days. However, in the study group,