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目的 :探讨 p2 1 ras在绝经前、后子宫内膜腺癌中的不同表达及意义。方法 :ABC免疫组织化学方法。结果 :子宫内膜腺癌组织中 p2 1 ras阳性表达率为 59.38%,而正常组织仅一例弱阳性 ;绝经后妇女子宫内膜腺癌组织中 p2 1 ras阳性表达率 ( 69.57%)及表达强度明显高于绝经前妇女( P<0 .0 5)。结论 :提示 p2 1 ras有作为子宫内膜腺癌尤其是绝经后子宫内膜腺癌诊断标志物及临床应用的可能性
Objective: To investigate the different expression and significance of p21 ras in premenopausal and post-menopausal women with endometrial adenocarcinoma. Methods: ABC immunohistochemical method. Results: The positive expression rate of p21 ras in endometrial adenocarcinoma was 59.38%, but only a weak positive in normal tissues. The positive expression rate of p21 ras in endometrial adenocarcinoma (69.57%) and the expression intensity Significantly higher than pre-menopausal women (P <0.05). Conclusions: This suggests that p21 ras may be a diagnostic marker for endometrial adenocarcinoma, especially postmenopausal endometrial adenocarcinoma, and its clinical application