头孢菌素类抗生素应用后易引起出血,如广谱的羟羧氧酰胺菌素(moxalactam)和易通过胆汁排出的头孢氧哌羟苯唑(cefoperazone)。由于它们对肠内细菌丛有抑制作用,导致维生素K合成障碍,尤其是食欲不振或不进饮食的病人或肝功能不全者更易缺少维生素K。再者,肝脏内合成凝血酶原,要有维生素K的存在;这类β-内酰胺抗生素3-位上的硫甲基四氮唑侧链也要用维生素K,因此大大影响了凝血酶原的合成。此外,在7位上有羧基侧链的β-内酰胺药物,还可通过腺苷二磷酸诱 Cephalosporin antibiotics cause bleeding after application, such as a broad spectrum of oxycodamycin (moxalactam) and cefeprazolam (cefoperazone), which is readily excreted through the bile. Vitamin K is more susceptible to vitamin K deficiency due to their inhibitory effect on intestinal flora, resulting in impaired vitamin K synthesis, especially in patients with poor appetite or ingestion or liver dysfunction. In addition, the synthesis of prothrombin in the liver, there must be the presence of vitamin K; 3-position of such β-lactam antibiotics also use thiamine methyl side chain of vitamin K, thus greatly affecting the prothrombin Synthesis. In addition, beta-lactam drugs with carboxyl side chains at position 7 may also be induced by adenosine diphosphate