观察服诱石剂实验动物及尿石合并积水病人肾组织的超微结构改变,发现一旦尿路梗阻和尿内草酸钙增加,将导致钙盐在梗阻的肾小管内沉积,相继发生肾小管上皮细胞形成泡状结构,微绒毛的脱落和消失,线粒体的空泡变,胞浆内出现较多高电子密度的溶酶体等改变。泡状结构引起肾小管腔壅塞,使细胞碎片和含钙高电子密度物质等沉积而形成微石。长期梗阻还可引起管周结缔组织增生和纤维化。 To observe the ultrastructural changes in kidney tissue of experimental animals and urolithiasis patients treated with superoxide dismutase and found that once the urinary tract obstruction and urinary calcium oxalate increased, it will lead to the deposition of calcium in the obstructed tubules, followed by tubules Epithelial cells formed vesicular structure, shedding and disappearance of microvilli, mitochondrial vacuolar changes, cytoplasmic more high electron density of lysosomes and other changes. Bubble-like structure caused renal tubular congestion, the cell debris and calcium-rich high electron density material deposition and the formation of microlithiasis. Long-term obstruction can also lead to peritubular connective tissue hyperplasia and fibrosis.