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最近意大利疾病中心报告了发生在血友病患者中的甲型肝炎大爆发。52例患者在确诊前2个月均输注了经沉淀-清除剂灭活病毒法制成的Ⅷ因子浓缩剂。本文通过对照研究以确定血友病患者HAV感染的根源,并对Ⅷ因子和发生甲肝的受血者血清标本反转录后经聚合酶链反应扩增的HAV-cDNA以分析病毒序列结果。
The Italian Center for Disease Control recently reported a large outbreak of hepatitis A in patients with hemophilia. Fifty-two patients were transfused with Factor-VIII concentrate inactivated by precipitation-scavenger virus two months prior to diagnosis. In this study, a control study was conducted to determine the origin of HAV infection in hemophiliacs and to analyze the viral sequence results by reverse transcription of factor VIII and the blood sample of the recipient recipient of hepatitis A (HAV-cDNA) amplified by polymerase chain reaction.