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肝细胞核因子是调节肝脏内基因特异性表达的一类转录因子,这些转录因子及其相互作用构成的复杂调控网络,精确地控制着肝脏的发育和肝细胞的功能。深入研究肝细胞核因子在胚胎发育和肝癌发生中的作用,可以为胚胎发育的基因调控和寻找更有效的肝癌诊断标志物、治疗靶点提供新思路。
Hepatocyte nuclear factor is a type of transcription factor that regulates gene-specific expression in the liver. These transcription factors and the complex regulatory networks formed by their interaction control precisely the development of the liver and the function of hepatocytes. In-depth study of the role of hepatocyte nuclear factor in embryonic development and hepatocellular carcinoma may provide new ideas for gene regulation of embryonic development and finding more effective diagnostic markers and therapeutic targets for liver cancer.