采用脉冲震荡法 ( IOS)测定 33例健康人、76例慢性阻塞性肺疾病 ( COPD)患者 IOS各项参数 ,对结果进行 t检验。结果显示慢支、肺气肿、肺心病之周边气道阻力明显增加 ,中心气道阻力轻度增加 ,阻抗 ( Zrs)和共振频率 ( Fres)明显增高 ,周边电抗下降。提示IOS能较好地反映气道阻力 ,方法简便 ,不需特殊配合 ,对 COPD的诊断有很好的应用价值 The parameters of IOS in 33 healthy people and 76 patients with chronic obstructive pulmonary disease (COPD) were measured by pulse oscillation method (IOS), and the results were analyzed by t test. The results showed that the peripheral airway resistance of chronic bronchitis, emphysema and pulmonary heart disease increased obviously, the central airway resistance increased slightly, the impedance (Zrs) and resonance frequency (Fres) increased obviously, and the peripheral reactance decreased. Suggesting that IOS can better reflect the airway resistance, the method is simple, without special coordination, the diagnosis of COPD has a good value