既往十多年来,在中枢神经系统中已证明有30余种肽的存在。这些神经肽起着神经递质或神经调节剂的作用。有关这类神经肽的确切作用尚待阐明。然而已有证据表明肽类对调节心血管中枢,呼吸功能,食物,水平衡,体温及记忆有关。近有证据提示内源性阿片样肽在休克和脊髓损伤发病机理中起作用。已证实鸦片受体拮抗剂纳络酮和促甲状腺释放激素肽能改善脊髓损伤后神经功能的恢复。阿片拮抗剂:实验研究Hosobuchi 等发现阿片拮抗剂纳络酮可改善沙土鼠颈动脉闭塞后的神经系统功能。根据以往观察,实验性脊髓损伤后,β-内腓肽样免疫反应性显著增高。纳络酮能明显改善脊髓血流供应和神经功能的恢复。脊髓损伤的病理生理与脑缺血有许多相同之处。作者采用 Hallenbeck 的方法,造成犬的血管闭塞模型。在缺血性损伤后1小时先给予每公斤2 Over the past decade or so, more than 30 peptides have been demonstrated in the central nervous system. These neuropeptides act as neurotransmitters or neuromodulators. The exact role of these neuropeptides remains to be elucidated. However, there is evidence that the peptides are involved in the regulation of the cardiovascular center, respiratory function, food, water balance, body temperature and memory. Nearly evidence suggests that endogenous opioid peptides play a role in the pathogenesis of shock and spinal cord injury. It has been demonstrated that the opioid receptor antagonists naloxone and thyrotropin releasing hormone peptide can improve the recovery of neural function after spinal cord injury. Opioid Antagonists: Experimental Studies Hosobuchi et al found that the opioid antagonist naloxone can improve the nervous system function of gerbil after carotid artery occlusion. Based on previous observations, beta-endorphin-like immunoreactivity was significantly increased after experimental spinal cord injury. Naloxone can significantly improve spinal cord blood supply and neurological recovery. The pathophysiology of spinal cord injury has many similarities with cerebral ischemia. The authors used Hallenbeck’s method to create a dog’s vascular occlusion model. One kilogram 2 is given 1 hour after ischemic injury