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组胺是广泛存在于人体的一种自体活性物质，也是引起过敏反应如鼻炎和荨麻疹的主要致病性递质。自从1937年Staub和Bovet发现了第一个组胺受体拮抗剂以来，相继有40余个品种进入医药市场，称其为第一代组胺H1受体拮抗剂，它易通过血脑屏障，阻断中枢H1受体，拮抗组胺的觉醒反应?
Histamine is an auto-active substance widely found in the human body and is also the major causative agent responsible for allergic reactions such as rhinitis and urticaria. Since Staub and Bovet discovered the first histamine receptor antagonist in 1937, more than 40 varieties have entered the pharmaceutical market one after another, calling it the first generation of histamine H1 receptor antagonists, which readily cross the blood-brain barrier, Block the central H1 receptor antagonist histamine awakening reaction?