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目的 :探讨肝动脉化疗栓塞 (TACE)配合无水酒精瘤内注射 (PEI)与 TACE合并灌注 IL- 2治疗中晚期原发性肝癌的临床疗效。方法 :采用 Seldinger插管至肝肿瘤供血动脉行灌注化疗 (卡铂 0 .3～ 0 .5 g,E- ADM6 0～ 80 mg,5 - Fu75 0～10 0 0 mg)加碘油栓塞术。在治疗组介入治疗后 2周 ,经 B超引导下行经皮肝穿刺瘤内注入无水酒精。对照组经 TACE同时灌注 IL- 2。结果 :治疗组有效率 (PR+MR)为 85 .7% (18/ 2 1) ,显著高于对照组 (5 5 % ,11/ 2 0 )。两组治疗有效率有显著性差异 (P <0 .0 5 ) ,治疗组 1,2年生存率 (80 % ,38% )亦高于对照组 (5 0 % ,10 % ,P <0 .0 5 )。结论 :TACE配合 PEI治疗肝癌疗效较高可能与无水酒精导致癌细胞变性坏死而起协同、增强作用有关。
Objective : To investigate the clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with intra-spinal alcohol injection (PEI) and TACE combined with perfusion of IL-2 in the treatment of advanced primary liver cancer. METHODS: Seldinger catheterization was performed to inject tumors into the hepatic tumors with arterial infusion chemotherapy (carboplatin 0.3-0.5 g, E-ADM6 0-80 mg, 5-Fu75-1000 mg) and lipiodol embolization. Two weeks after interventional treatment in the treatment group, anhydrous alcohol was injected into the tumor via percutaneous puncture under ultrasound guidance. In the control group, IL-2 was infused simultaneously by TACE. Results: The effective rate of the treatment group (PR+MR) was 85.7% (18/21), which was significantly higher than that of the control group (55%, 11/20). There was a significant difference in treatment efficiency between the two groups (P < 0.05). The 1-year and 2-year survival rates (80 % and 38 %) in the treatment group were also higher than those in the control group (50 %, 10 %, P <0. 0 5 ). Conclusion : The high curative effect of TACE combined with PEI in the treatment of liver cancer may be related to the synergistic and enhancing effect of anhydrous alcohol leading to degeneration and necrosis of cancer cells.