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目的分析脑脊液MBP、NSE与颅内感染患者的预后相关性。方法选取医院收治的颅内感染患者45例为观察组;以同期医院收治的疑似颅内疾病患者45例为对照组。采用酶联免疫吸附试验检测2组脑脊液髓鞘碱性蛋白(MBP)、神经特异性烯醇化酶(NSE)水平,分析脑脊液MBP、NSE在颅内感染患者中的诊断效果及与预后的相关性。结果观察组脑脊液MBP、NSE水平,均高于对照组(P<0.01);观察组治疗后36例预后较好,9例预后差。预后良好亚组脑脊液MBP、NSE水平,均低于预后差亚组(P<0.01),预后良好亚组MMSE评分,高于预后差亚组(P<0.01);颅内感染患者预后与脑脊液MBP、NSE水平呈正相关性(r=5.124,P均<0.05)。结论脑脊液MBP、NSE能评估颅内感染患者病情变化情况,可评估患者预后,为临床调整治疗方案提供依据,值得临床推广应用。
Objective To analyze the correlation between CSF MBP and NSE in patients with intracranial infection. Methods Forty-five patients with intracranial infection admitted to hospital were selected as observation group and 45 patients with suspected intracranial disease admitted to hospital at the same period as control group. The levels of myelin basic protein (MBP) and neuron specific enolase (NSE) in cerebrospinal fluid of two groups were detected by enzyme-linked immunosorbent assay (ELISA), and the diagnostic value of cerebrospinal fluid MBP and NSE in patients with intracranial infection was analyzed and their correlation with prognosis . Results The cerebrospinal fluid levels of MBP and NSE in the observation group were higher than those in the control group (P <0.01). The observation group had a good prognosis of 36 cases and poor prognosis in 9 cases. The levels of MBP and NSE in cerebrospinal fluid of patients with good prognosis were lower than those in the poor prognosis group (P <0.01), MMSE scores in the good prognosis group were higher than those in the poor prognosis group (P <0.01) , NSE levels were positively correlated (r = 5.124, P <0.05). Conclusions Cerebrospinal fluid MBP and NSE can assess the changes of patients with intracranial infection, evaluate the prognosis of patients and provide the basis for clinical treatment regimen, which is worthy of clinical application.