6种阿莫西林胶囊及片剂的溶出度比较

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本文采用分光光度法测定了6个厂家阿莫西林的3种胶囊以及3种片剂(普通片、速溶片、可溶片)的体外溶出度,方差分析表明,6个厂家的产品在45min时的累积溶出量无显著性差异(P>0.05);胶囊剂与片剂之间的溶出速率有极显著性差异(P<0.01)。尤其是速溶片及可溶片的初始溶出速度比普通片剂及胶囊剂快。初始释药速率依次为F>E>D>A>B>C厂。 In this paper, the in vitro dissolution of three kinds of capsules and three kinds of tablets (normal tablets, instant tablets and soluble tablets) of 6 manufacturers were determined by spectrophotometry. The analysis of variance showed that the accumulations of products of 6 manufacturers at 45min There was no significant difference in dissolution rate (P> 0.05). There was a significant difference in dissolution rate between capsules and tablets (P <0.01). Especially instant tablets and soluble tablets initial dissolution rate faster than ordinary tablets and capsules. The initial release rates were F> E> D> A> B> C.
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