目的　探讨呼吸门控下定量CT对接尘工人早期病变的诊断价值。方法　接尘工人 6 2例 (接尘 3～ 2 8年 )及对照组 5 4例 ,在 5 0 %肺活量 (5 0 %VC)状态下行全肺螺旋CT扫描 ,在 10 %VC、90 %VC呼吸水平下于隆突层和隆突上、下各 5cm处行高分辨CT(HRCT)扫描。用定量指标分析结果 ,并与临床肺功能检测进行对照。结果　 6 2例接尘工人中有 9例在CT上可见肺气肿的表现。接尘工人的 10 %VC、90 %VC时的定量指标与对照组的差异均有显著性 (P <0 .0 5 ) ,并且随着接尘工龄的增加 ,其定量指标与对照组的差异呈梯度增加。结论　呼吸门控定量CT是接尘工人早期病变的灵敏、准确、客观的检查方法 ,其对小气道病变的诊断优于临床肺功能检测。 Objective To investigate the diagnostic value of quantitative respiratory CT-guided CT in early detection of dust-exposed workers. Methods Sixty-two patients (3-38 years of dust exposure) and 54 cases of control group were enrolled in this study. Whole-lung spiral CT scan was performed under 50% vital capacity (50% VC) Respiratory level in the carina layer and carina, 5 cm under high-resolution CT (HRCT) scan. Quantitative analysis of the results, and clinical lung function tests were compared. Results Six of 62 workers exposed to dust showed CT manifestations of emphysema. The difference between the quantitative indexes of 10% VC and 90% VC of workers exposed to dust and the control group was significant (P <0.05), and with the increase of the service life of dust, the difference between the quantitative index and the control group Gradient increase. Conclusion Respiratory gated quantitative CT is a sensitive, accurate and objective method for early detection of dust-exposed workers. Its diagnosis of small airway lesions is superior to clinical pulmonary function tests.