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目的探讨急性脑卒中患者的血清N末端B型利钠肽(NT-pro BNP)的变化,评价血清NT-pro BNP测定的临床意义。方法74例患者分别为急性脑梗死(CI)(42例)和急性脑出血(ICH)组(32例),根据入院时NIHSS评分分为轻度、中度和重度3个亚组,采用ECLIA法检测发病48h内(急性期)及发病第21天(亚急性期)的血清NT-pro BNP水平,与健康对照组进行比较,比较急性期与亚急性期间、各亚组间的血清NT-pro BNP水平差异。结果CI组和ICH组急性期血清NT-pro BNP显著高于对照组(P<0.01),并在亚急性期显著下降(P<0.01);各亚组间急性期血清NT-pro BNP水平均有显著统计学差异(P<0.01)。结论急性期脑卒中患者急性期血清NT-pro BNP水平与病情程度相关。
Objective To investigate the changes of serum N-terminal B-type natriuretic peptide (NT-pro BNP) in patients with acute stroke and to evaluate the clinical significance of serum NT-pro BNP. Methods 74 patients were divided into three groups: acute cerebral infarction (CI) (42 cases) and acute cerebral hemorrhage (ICH) (32 cases). According to the NIHSS score at admission, the patients were divided into mild, moderate and severe subgroups. Method to detect serum NT-pro BNP levels within 48h after onset (acute phase) and onset on day 21 (subacute phase), and compared with healthy control group. During the acute and subacute periods, serum NT- pro BNP level difference. Results The levels of serum NT-pro BNP in the acute phase of CI group and ICH group were significantly higher than those of the control group (P <0.01), and significantly decreased in the subacute phase (P <0.01). The serum levels of NT-pro BNP There was a significant difference (P <0.01). Conclusion The level of serum NT-pro BNP in patients with acute stroke is related to the severity of the disease.