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目的探讨白细胞介素 -8(IL -8)及白细胞介素 -10 (IL -10 )在支气管哮喘发病机制中的作用。方法搜集 3 0例支气管哮喘急性发作期患者 ,2 8例支气管哮喘缓解期患者和 2 0例健康者的静脉血 ,离心后取血清 ,采用放射免疫法测定其中 IL -8及 IL -10水平 ,同时对以上人员常规测定血中 PO2 、PCO2 以及一秒钟用力呼气容积占预计值百分比 (FEV1占预计值 % ) ,并把它与 IL -8及 IL -10进行相关性比较。结果支气管哮喘急性发作期患者血清 IL-8水平明显高于缓解期及健康对照组 ,IL -10水平明显低于缓解期及健康对照组 ,均有显著性差异。而哮喘急性发作期患者治疗后血清 IL -8水平明显低于治疗前 ,血清 IL -10明显高于治疗前。支气管哮喘急性发作期患者FEV1占预计值 %明显低于其它两组 ,有显著性差异。血清中 IL-8水平与 FEV1占预计值 %呈负相关 ,而 IL-10水平与 FEV1占预计值 %呈正相关。结论 IL -8与 IL -10参与了支气管哮喘气道炎症反应。
Objective To investigate the role of interleukin-8 (IL-8) and interleukin-10 (IL-10) in the pathogenesis of bronchial asthma. Methods Thirty patients with acute exacerbation of bronchial asthma, 28 patients with bronchial asthma remission and 20 healthy controls were enrolled in this study. Serum was collected after centrifugation and IL -8 and IL -10 levels were measured by radioimmunoassay. At the same time on the above routine determination of blood PO2, PCO2 and forced expiratory volume per second as a percentage of the expected value (FEV1 accounting for the expected%), and its correlation with IL -8 and IL -10. Results Serum levels of IL-8 in patients with acute exacerbation of bronchial asthma were significantly higher than those in remission and healthy controls, and IL-10 levels were significantly lower than those in remission and healthy controls. Serum IL-8 levels in patients with acute exacerbation of asthma were significantly lower than before treatment, serum IL-10 was significantly higher than before treatment. Exacerbation of bronchial asthma in patients with FEV1% predicted value was significantly lower than the other two groups, there was a significant difference. The level of IL-8 in serum was negatively correlated with the predicted value of FEV1, while the level of IL-10 was positively correlated with the predicted value of FEV1. Conclusion IL-8 and IL-10 are involved in airway inflammation in bronchial asthma.