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目的探讨炎症因子IL-2、IL-6、IL-18、TNF-A在儿童肺炎支原体肺炎中的变化及其临床意义。方法选择广州市越秀区儿童医院儿科肺炎支原体肺炎住院患儿50例为观察组,同时选取正常患儿50例作为对照组,采用酶联免疫法检测患儿急性期、恢复期及正常儿童血清的IL-2、IL-6、IL-18、TNF-A水平。结果与对照组相比,肺炎支原体肺炎患儿血清IL-2水平显著降低,而IL-6、IL-18、TNF-A水平均不同程度升高,p<0.05。结论 IL-2、IL-6、IL-18、TNF-A参与了肺炎支原体肺炎的发生、发展,检测相关血清炎症因子水平对判定病情和预后有一定的临床价值。
Objective To investigate the changes and clinical significance of inflammatory cytokines IL-2, IL-6, IL-18 and TNF-A in children with Mycoplasma pneumoniae pneumonia. Methods Fifty children hospitalized with pediatric pneumonia mycoplasma pneumonia in Children’s Hospital of Yuexiu District of Guangzhou were selected as the observation group. Fifty normal children were selected as the control group. Enzyme linked immunosorbent assay was used to detect the serum levels of acute, convalescent and normal children IL-2, IL-6, IL-18, TNF-A levels. Results Compared with the control group, the serum IL-2 level of children with Mycoplasma pneumoniae pneumonia was significantly decreased, while the levels of IL-6, IL-18 and TNF-A increased to some extent, p <0.05. Conclusion IL-2, IL-6, IL-18 and TNF-A are involved in the pathogenesis and development of Mycoplasma pneumoniae pneumonia. It is of clinical significance to determine the level of serum inflammatory cytokines in determining the disease and prognosis.