论文部分内容阅读
目的：碘［１３１Ｉ］肝癌细胞膜单抗Ｈｅｐａｍａ１注射液及其肝癌细胞膜单抗Ｈｅｐａｍａ１溶液注射小鼠后的急性毒性试验。方法：小鼠一次尾静脉注入肝癌细胞膜单抗Ｈｅｐａｍａ１溶液０．４ｍｇ单抗／２０ｇ或碘［１３１Ｉ］肝癌细胞膜单抗Ｈｅｐａｍａ１注射液７４ＭＢｑ／２０ｇ，观察小鼠的急性毒性反应。结果：试验组鼠全部存活，一般状态正常，体重增长，未见明显急性毒副反应。结论：该药品及其载体在指定的给药方式条件下，在小鼠体内没有引起明显的急性毒副反应
OBJECTIVE: To evaluate the acute toxicity of 131I hepatoma cell membrane monoclonal antibody Hepama1 injection and hepatocellular carcinoma monoclonal antibody Hepama1 solution injection. METHODS: The mice were treated with a hepatoma cell membrane monoclonal antibody Hepama 1 solution of 0.4 mg monoclonal antibody/20g or iodine [131I] hepatoma cell membrane monoclonal antibody Hepama 1 injection 74 MBq/20 g. The mice were observed for acute toxicity. RESULTS: All rats in the experimental group survived, were in normal condition, and gained weight. No obvious acute toxicity was observed. Conclusion: The drug and its carrier did not cause obvious acute side effects in mice under the specified conditions.