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目的探讨糖化血红蛋白(HbA_(1c))对行经皮冠状动脉介入治疗术(PCI)的冠心病患者预后的影响。方法选取2014年10月—2015年11月驻马店市第一人民医院收治的行PCI的冠心病患者90例,根据糖尿病患病情况和血清HbA_(1c)水平分为A组(合并糖尿病且HbA_(1c)<6.5%)、B组(合并糖尿病且HbA_(1c)≥6.5%)、C组(未合并糖尿病且HbA_(1c)<6.5%),每组30例。比较3组患者术后6、24个月不良心血管事件发生率。结果 3组患者术后6个月心因性死亡率、支架内血栓形成发生率比较,差异无统计学意义(P<0.05);A、B组患者新发心血管疾病、非致死性心肌梗死、靶血管再狭窄发生率高于C组(P<0.017)。3组患者术后24个月心因性死亡、支架内血栓形成、靶血管再狭窄发生率比较,差异无统计学意义(P<0.05);A、B组患者新发心血管疾病、非致死性心肌梗死发生率高于C组(P<0.017)。结论糖尿病和血清HbA_(1c)水平升高可增加行PCI的冠心病患者术后不良心血管事件发生率。
Objective To investigate the effect of glycosylated hemoglobin (HbA_ (1c)) on the prognosis of patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Methods Ninety patients with coronary artery disease undergoing PCI from the First People’s Hospital of Zhumadian City from October 2014 to November 2015 were selected and divided into three groups according to the prevalence of diabetes and serum HbA 1c levels: group A with diabetes and HbA_ ( 1c) <6.5%), group B (with diabetes and HbA 1c≥6.5%), group C (without diabetes and HbA 1c <6.5%). The incidence of adverse cardiovascular events at 6 and 24 months after operation was compared between the three groups. Results There was no significant difference in the incidence of psychogenic mortality or stent thrombosis at 6 months postoperatively among the three groups (P <0.05). The incidence of cardiovascular disease, non-fatal myocardial infarction , And the incidence of target vascular restenosis was higher than that of C group (P <0.017). There were no significant differences in the incidence of cardiac death, stent thrombosis, and target vascular restenosis between the three groups at 24 months postoperatively (P <0.05). In group A and group B, newly-occurring cardiovascular diseases were non-fatal The incidence of myocardial infarction was higher in group C than in group C (P <0.017). Conclusion The increase of diabetes and serum HbA 1c levels may increase the incidence of adverse cardiovascular events in patients with coronary artery disease after PCI.