论文部分内容阅读
目的:观察胃癌术后不同因素对患者生存率的影响,为综合评价患者的预后及中药的临床作用提供依据。方法:回顾性分析194例胃癌术后患者的临床随访资料,采用SPSS 16.0软件对已建立的病例数据库数据进行统计分析,应用Kaplan-Meier方法计算1、3,5、10年生存率,并对相关因素进行生存率的单因素分析,比较采用Log-rank方法检验,以α=0.05为检验水准,对单因素分析有统计学意义的影响因素进行Cox回归模型多因素分析。结果:单因素分析结果显示,性别差异对术后胃癌患者的预后无显著影响(P>0.05),而手术方式,TNM分期,肝转移与否,淋巴结转移及中药对其预后有影响(P<0.05)。经Cox回归多因素分析发现:手术方式,中药参与治疗为影响患者术后生存的独立预后因素。结论:手术和中药是影响患者术后生存率的重要因素,中药可以延长胃癌术后患者的生存期,且服用中药的时间长短与生存期长短有关联性。
Objective: To observe the effect of different factors on the survival rate of patients with gastric cancer, and to provide a basis for the comprehensive evaluation of the prognosis of patients and the clinical effect of traditional Chinese medicine. Methods: The clinical follow-up data of 194 patients with postoperative gastric cancer were retrospectively analyzed. The data of the established case database were analyzed by SPSS 16.0 software. The 1, 3, 5, 10 year survival rates were calculated by Kaplan-Meier method. Univariate analysis was used to evaluate the survival rate of the patients. Log-rank test was used to compare the factors of statistical significance with univariate analysis with α = 0.05 as the test standard. Cox regression model was used to analyze the factors. Results: The results of univariate analysis showed that the gender difference had no significant effect on the prognosis of patients with gastric cancer (P> 0.05), but the operation method, TNM stage, liver metastasis, lymph node metastasis and Chinese medicine had an impact on the prognosis (P < 0.05). Cox regression multivariate analysis found that: surgical methods, treatment of Chinese medicine as independent prognostic factors affecting the survival of patients. Conclusion: Surgery and traditional Chinese medicine are important factors that influence the postoperative survival rate of patients. Traditional Chinese medicine can prolong the survival of patients with gastric cancer after surgery. The duration of taking traditional Chinese medicine and the length of life of the patients are related to each other.