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1986年7～12月,对加用肝素治疗的42例肾病综合征患者作了系统血液流变学观察,证明肝素有明显降低血粘度的作用。报告如下。资料与方法一、病例选择:按全国第二届肾病学术会议标准,42例中原发性肾病综合征Ⅰ型7例、Ⅱ型35例。其中男33例,女9例。成人39例,儿童3例。病程6月～16年,平均2.9年。其中18例为经激素及免疫抑制剂治疗无效的难治性病例。二、实验方法:采用上一医生物物理教研组与上海供电局产NX-3型血粘度-细胞电泳自动计时仪,专人按规定方法操作。同时测血浆纤维蛋白原。另以27名本院职工为健康对照组。三、治疗方法:肝素100～150mg/日,分2～3次腹壁皮下脂肪注射;强的松30～45mg/日;环磷酰胺0.2/间日静注。疗程2～3月。
From July to December 1986, 42 patients with nephrotic syndrome treated with heparin were given systematic hemorheological observations, demonstrating that heparin significantly reduced blood viscosity. The report is as follows. Materials and Methods A case selection: According to the national second session of the Nephrology Conference, 42 cases of primary nephrotic syndrome type Ⅰ in 7 cases, type Ⅱ 35 cases. There were 33 males and 9 females. 39 cases of adult, 3 cases of children. Course of disease from June to 16 years, an average of 2.9 years. Among them, 18 cases were refractory to hormone and immunosuppressive therapy. Second, the experimental method: the use of a medical physics physics and teaching research group and the Shanghai Power Supply Bureau production NX-3 blood viscosity - cell electrophoresis automatic timer, the person according to the provisions of the method of operation. At the same time measuring plasma fibrinogen. The other 27 hospital staff for the control group. Third, the treatment: heparin 100 ~ 150mg / day, 2 to 3 abdominal subcutaneous fat injection; prednisone 30 ~ 45mg / day; cyclophosphamide 0.2 / day intravenous injection. Course of 2 to 3 months.