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目的本文旨在分析胰岛素联合阿托伐他汀对于糖尿病合并冠心病患者内皮功能和疗效的影响。方法选取在我院接受治疗的糖尿病合并冠心病患者78例,分为两组,分别采用胰岛素联合阿托伐他汀和单纯使用胰岛素,观察实验组和对照组的内皮功能和血脂、血糖水平。结果实验组的总胆固醇、甘油三酯、低密度脂蛋白和血糖水平显著低于对照组,高密度脂蛋白水平、反应性充血后肱动脉内径变化百分率、一氧化氮水平和硫化氢水平显著高于对照组(P<0.05)。结论胰岛素联合阿托伐他汀可以明显提高糖尿病合并冠心病患者的内皮功能和治疗效果。
Objective This article aims to analyze the effect of insulin plus atorvastatin on endothelial function and efficacy in patients with diabetes mellitus and coronary heart disease. Methods Totally 78 patients with diabetes mellitus and coronary heart disease undergoing treatment in our hospital were divided into two groups. Insulin combined with atorvastatin and insulin alone were used to observe the endothelial function and blood lipid and blood glucose levels in experimental group and control group. Results The levels of total cholesterol, triglyceride, low density lipoprotein and blood glucose in the experimental group were significantly lower than those in the control group. The levels of HDL, percentage of brachial artery diameter after reactive hyperemia, nitric oxide and hydrogen sulfide were significantly higher In the control group (P <0.05). Conclusions Insulin combined with atorvastatin can significantly improve endothelial function and therapeutic effect in diabetic patients with coronary heart disease.