论文部分内容阅读
Objective To study the effect of oral vitamin D(VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weightmen.Methods Twenty-one obese men with their body mass index(BMI)>28 kg/m2served as an obese group and 22 healthy normal-weight men with their BMI<24 kg/m2served as a control group in this study.After they were given 50 000 IU of oral VD,once a week for 8 weeks,the serum25-hydroxyvitamin D [25(OH)D] concentration was measured with an enzyme-immunoassay kit.Results After oral VD supplementation,the serum 25(OH)D concentration significantly increased from46.1±9.1 nmol/L to 116.7±20.3 nmol/L in the obese subjects(P<0.01) and from 52.8±17.8 nmol/L to181.3±30.2 nmol/L in the control ones(P=0.13).The serum high-density lipoprotein cholesterol(HDL-C)level was reduced within the normal reference range in the obese group.However,no significant change was observed in the level of other serum lipids(triglycerides,total cholesterol,and low-density lipoprotein cholesterol) in either of the two groups.Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group.High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
Objective To study the effect of oral vitamin D (VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weight men. Methods Twenty-one obese men with their body mass index (BMI)> 28 kg / m2served as an obese group and 22 healthy normal-weight men with their BMI <24 kg / m2served as a control group in this study. After they were given 50 000 IU of oral VD, once a week for 8 weeks, the serum 25-hydroxyvitamin D [25 OH) D concentration was measured with an enzyme-immunoassay kit. Results After oral VD supplementation, the serum 25 (OH) D concentration increased from 46.1 ± 9.1 nmol / L to 116.7 ± 20.3 nmol / L in the obese subjects The serum high-density lipoprotein cholesterol (HDL-C) level was reduced within the normal reference range (P <0.01) and from 52.8 ± 17.8 nmol / L to 181.3 ± 30.2 nmol / L in the control ones in the obese group. However, no significant change was observed in the level of other serum lipids (triglycerides, total cholesterol, and low-density lipoprotei n cholesterol) in either of the two groups. Confc The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group. High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.