先心病伴肺动脉高压患者ET-1、VEGF、eNOS表达研究

来源 :医药前沿 | 被引量 : 0次 | 上传用户:syh95815
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:通过检测先心病伴肺动脉高压患者血清ET-1、VEGF、eNOS表达,探讨先心病肺动脉高压发生的可能机制.方法:患先天性心脏病患者,经心脏彩超评估PASP,据PASP水平将患者分为正常组(n=12)、轻度PAH组(n=12)、中度PAH组(n=12)、重度PAH组(n=12).应用ELISA法进行血清ET-1、VEGF、eNOS检测,统计、分析血清ET-1、VEGF、eNOS与肺动脉压改变关系.结果:各组血清ET-1、VEGF、eNOS比较,轻度、中度、重度PAH组各指标均呈逐渐增高,中度、重度PAH组各指标较正常组均增高,血清VEGF轻度PAH组较正常组增高,差异均具有统计学意义.中度、重度PAH组RA、RV较正常组和轻度PAH组增大.结论:先心病伴肺动脉高压患者随着PASP增高,血清ET-1、VEGF、eNOS表达增加,且与PASP存在正相关;ET-1、VEGF、eNOS参与PAH的形成,三者可能存在相互促进作用.“,”Objective To detect serum ET-1, VEGF, eNOS expression of the patients with congenital heart disease(CHD)pulmonary Artery hypertension(PAH), and explore the possible mechanism of PAH .Methods Patients with CHD were assessed the pulmonary artery systolic pressure(PASP)by the echocardiography.All patients were divided into normal group (n=12), mild PAH group (n=12), moderate PAH group (n=12), and severe PAH group (n=12)according to PASP levels.Serum ET-1, VEGF, eNOS expression were detected by ELISA. Statistical analysis was done to explore the relationship between them and pulmonary arterial pressure.Results Serum ET-1, VEGF, eNOS expression in the mild,moderate and severe PAH group showed that the indexs gradually increased.Serum ET-1, VEGF, eNOS expression in the moderate and severe PAH group were significantly higher than that in the normal group.Serum VEGF in the mild PAH group was higher than that in the normal group.All the differences were statistically significant. The diameters Of right atrium and right ventricule in the moderate and severe PAH group were larger than that in the normal group and mild PAH group.Conclusions The PASP of patients with CHD PAH were increased,serum ET-1, VEGF, eNOS expression were increased,the PASP was positively correlated with the serum ET-1,VEGF and eNOS expession.the ET-1, VEGF and eNOS were involved in the formation of PAH,three indexs maybe reinforce mutually.
其他文献
期刊
案件回放2010年5月4日晚,车主董某聘请的司机刘某驾驶货车,行至湖北省武汉市岱黄高速公路府河桥上与倪某发生纠纷。司机刘某报警,并给车主打电话通报情况,请求协助。董某因故
期刊
目的:探索分析不孕不育夫妇生殖道感染解脲支原体和沙眼衣原体的相关性.方法:选择2014年1月到2015年1月期间在我院进行查体和治疗的200对夫妇为研究对象,将其分为观察组和对
期刊
目的:分析老年骨质疏松性骨折的危险因素,探讨护理干预措施.方法:以医院收治的146例老年骨质疏松性骨折患者为研究对象,采取问卷调查的方式分析老年骨质疏松性骨折患者的危险
保密工作历来是国家和企业的一项重要工作,事关国家安全,事关企业发展.重视保密工作不仅关系到企业的利益还关系到员工个人的利益,因此,为适应当前形势的发展变化,必须要进一
目的:观察分析四君子汤合痛泻要方治疗腹泻型肠易激综合征的临床效果.方法:选取我院于2013年1月至2014年1月期间收治的腹泻型肠易激综合征患者36例,按治疗方法的不同,分为对
期刊