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目的研究磁共振帕金森指数(magnetic resonance Parkinsonism index,MRPI)对进行性核上性麻痹(progressive supranuclear plasy,PSP)诊断及预后的提示价值。方法搜集临床PSP 8例,额颞叶痴呆(fron-totemporal dementia,FTD)5例,帕金森病(Parkinson’s disease,PD)10例,多系统萎缩(multiple system atrophy,MSA)6例,行MR检查并计算MRPI值;采用PSP评定量表(progressive supranuclear plasy rating scale,PSPRS)评分,并与MRPI值行相关分析;对患者进行电话随访,分析MRPI值与生存时间关系。结果 PSP组MRPI值显著高于其余各组,PSP组数值与各组进行t检验(PD组P=0.0024;FTD组P=0.0032;MSA组P=0.0028);PSP组MRPI值与PSPRS得分呈正相关(r=0.7946,经t检验P=0.017);以MRPI值18.175分为界值将PSP组分为两个亚组,亚组间平均生存时间无统计学差异(Log-Rank Test检验,P=0.308)。结论 MRPI可以提高PSP的诊断准确率。
Objective To investigate the value of magnetic resonance Parkinsonism index (MRPI) in the diagnosis and prognosis of progressive supranuclear plasy (PSP). Methods 8 cases of clinical PSP, 5 cases of frontal temporal lobe dementia (fronto-totemporal dementia), 10 cases of Parkinson’s disease (PD) and 6 cases of multiple system atrophy (MSA) And calculated the value of MRPI. The score of PSPRS was used to analyze the relationship between MRPI and survival time. The patients were followed up by phone. Results The MRPI of PSP group was significantly higher than that of the other groups. The PSP group showed t-test (P = 0.0024 for PD group and P = 0.0032 for FTD group; P = 0.0028 for MSA group) (r = 0.7946, P = 0.017 by t-test). The PSP group was divided into two subgroups with the cut-off value of 18.175. There was no significant difference in the average survival time among subgroups (Log-Rank Test, P = 0.308). Conclusion MRPI can improve the diagnostic accuracy of PSP.