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文章简介细胞内过多的活性氧(ROS)与神经系统疾病、心脏疾病的发生发展密切相关。心肌缺血损伤早期,心肌细胞中会产生大量的ROS,可以诱导心肌细胞凋亡及坏死,造成心肌梗死。ROS直接作用于细胞内的生物大分子(蛋白质、DNA和RNA)并对其进行氧化修饰,影响这些生物分子的活性及功能,从而对细胞的功能产生影响。miRNA作为近年来广泛研究的一类小分子非编码RNA,具有重要生物学功能。
Article Description Intracellular excessive reactive oxygen species (ROS) are closely related to the occurrence and development of nervous system diseases and heart diseases. Early myocardial ischemia, myocardial cells will produce a lot of ROS, can induce cardiomyocyte apoptosis and necrosis, causing myocardial infarction. ROS act directly on intracellular biological macromolecules (proteins, DNA and RNA) and their oxidative modification, affecting the activity and function of these biomolecules, thereby affecting the function of cells. As a kind of small molecule non-coding RNA widely studied in recent years, miRNA has important biological functions.