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目的选择30例2型糖尿病并发糖尿病周围神经病变(DPN)的患者,连续注射ɑ—硫辛酸3周后,观察其对2型糖尿病患者周围神经病变的疗效。方法 30例2型糖尿病患者入院后给予ɑ—硫辛酸注射液24ml静滴,日1次,疗程3周。同时记录治疗前后下肢及足部感觉障碍、麻木、疼痛、烧灼感和运动神经、感觉神经传导速度的变化。结果治疗前后患者的临床疗效、神经传导速度改善明显,差异有统计学意义(P<0.05)。结论抗氧化剂ɑ—硫辛酸能明显改善2型糖尿病患者周围神经病变。
Objective To select 30 patients with type 2 diabetes mellitus complicated with diabetic peripheral neuropathy (DPN) and observe the curative effect on peripheral neuropathy in patients with type 2 diabetes mellitus after continuous injection of ɑ-lipoic acid for 3 weeks. Methods 30 patients with type 2 diabetes were given intravenous injection of ɑ-lipoic acid 24ml intravenously once daily for 3 weeks. At the same time, the changes of sensory nerve conduction velocity and sensory nerve conduction velocity in lower limbs and feet, numbness, pain, burning sensation and motor nerve were recorded before and after treatment. Results Before and after treatment, the clinical curative effect and nerve conduction velocity were significantly improved (P <0.05). Conclusion Antioxidant ɑ-lipoic acid can significantly improve peripheral neuropathy in patients with type 2 diabetes mellitus.