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Sutherland等人首先在细胞培养中对脆性部位(17)(p12)进行了实验诱导,发现这个部位类似罕见型脆性部位(16)(q22)。两个部位都可用远霉素A、纺锤菌素、Hoechst33258和BrdU诱导。然而,关于fra(17)(p12)的群体频率资料很少。本实验分析了用AT特异性DNA配体诱导fra(17)(p12)的情况,且用Berenil对250例(164男,86女)随机选择的非亲缘关系的正常个体的淋巴细胞进行了处理,同时选择了7名经细胞遗传学检查确定是fra(17)(p12)阳性的杂合子个
Sutherland et al. First experimentally induced the fragile site (17) (p12) in cell culture and found it to resemble a rare type of fragile site (16) (q22). Both parts can be induced with tobramycin A, penicillin, Hoechst 33258 and BrdU. However, there is very little information on the frequency of the group fra (17) (p12). This experiment analyzed the case of fra (17) (p12) induced by AT-specific DNA ligands and treated non-related lymphocytes of 250 normal individuals (164 males and 86 females) randomly selected with Berenil , And seven heterozygotes that were confirmed by cytogenetic tests to be fra (17) (p12) positive