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目的:应用超声心动图评定和区分病理性和生理性左室肥大。方法:20只雄性SD大鼠随机分为3组:训练组,8只SD大鼠完成8周大强度游泳训练;2K1C组,6只SD大鼠建立“两肾一夹”高血压动物模型;对照组,6只SD大鼠做假手术组。8周后,应用常规和组织多普勒超声心动图检测所有大鼠。结果:超声心动图结果显示2K1C组和训练组心脏重量左室室间隔以及左室后壁厚度均增加,左室质量分别增加36%和41%。二尖瓣瓣口血流速度显示训练组舒张晚期血流速度降低,从而导致舒张早期血流速度/舒张晚期血流速度(E/A)比值增加。但是2K1C组二尖瓣瓣口血流速度显示舒张晚期血流速度增加,从而导致E/A比值降低。训练组显著增加二尖瓣瓣环基底部和侧壁瓣环舒张早期运动速度(Ea)和舒张早期运动速度/舒张晚期运动速度(Ea/Aa)比值增加,但2K1C组二尖瓣瓣环基底部和测壁瓣环舒张晚期运动速度(Aa)显著增加,从而导致舒张早期运动速度/舒张晚期运动速度(Ea/Aa)比值降低。结论:左室舒张功能多普勒超声心动图参数对于区分病理性和生理性左室肥大具有重要诊断意义。
OBJECTIVE: To assess and distinguish between pathological and physiological LV hypertrophy using echocardiography. Methods: Twenty male Sprague-Dawley rats were randomly divided into 3 groups: training group, 8 SD rats completed intensive swimming training for 8 weeks; 2K1C group, 6 SD rats established “two kidney one clip” Model; control group, 6 SD rats were sham operation group. After 8 weeks, all rats were examined using both routine and Tissue Doppler echocardiography. Results: Echocardiography showed that left ventricular septum and left ventricular posterior wall thickness were increased in both 2K1C and training groups, and left ventricular mass increased by 36% and 41%, respectively. The mitral valve orifice blood flow velocity showed a decrease in late diastolic flow velocity in the training group, resulting in an increased ratio of early / early diastolic flow velocity (E / A). However, the velocities of mitral valve orifice in 2K1C group showed an increase of diastolic blood flow velocity, which resulted in the decrease of E / A ratio. The training group significantly increased the ratio of early diastolic velocity (Ea) and early diastolic velocity / late diastolic velocity (Ea / Aa) in the mitral valve annulus and the lateral annulus, but the mitral annular base Lateral diastolic velocity (Aa) increased significantly in the stenosis and valvular rings, resulting in a decrease in early diastolic velocity / late diastolic velocity (Ea / Aa). Conclusions: Doppler echocardiographic parameters of left ventricular diastolic function have important diagnostic significance for distinguishing between pathological and physiological LVH.