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目的观察脑心通胶囊治疗老年冠心病的临床效果。方法选择自2009年8月—2011年8月明确诊断的老年冠心病患者202例,随机分为治疗组和对照组,各101例。对照组采用常规治疗,口服单硝酸异山梨酯缓释片60 mg,每日1次;阿司匹林肠溶片100 mg,每日1次,如有高血压、糖尿病、高脂血症,另给予合理的降压、降糖、降脂(他汀类降脂药)药物治疗。治疗组在对照组治疗的基础上,加服脑心通胶囊4粒,每日3次。两组均治疗半年。治疗期间所有患者均每月随访1次,观察症状的改善情况、血压值的变化、血脂水平的变化、心电图表现、对睡眠的影响以及有无心血管意外事件的发生。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果对照组临床总有效率为46.5%,治疗组94.1%,两组比较差异有统计学意义(P<0.05)。治疗后治疗组血脂水平、血压与对照组相比,差异均有统计学意义(均P<0.05)。治疗组心电图、睡眠质量改善情况均优于对照组(均P<0.05)。结论脑心通胶囊治疗老年冠心病能够有效缓解症状,改善心电图表现,促进患者康复,效果满意,且安全可靠。
Objective To observe the clinical effect of Naoxintong capsule on senile coronary heart disease. Methods Twenty-two elderly patients with coronary heart disease diagnosed from August 2009 to August 2011 were randomly divided into treatment group (n = 101) and control group (n = 101). The control group was treated with conventional treatment, oral administration of isosorbide mononitrate sustained-release tablets 60 mg once daily; aspirin enteric-coated tablets 100 mg once daily, if hypertension, diabetes, hyperlipidemia, the other to give reasonable Of antihypertensive, hypoglycemic, lipid-lowering (statins lipid-lowering drugs) drug treatment. Treatment group in the control group based on the treatment, plus service Naoxintong capsule 4, 3 times a day. Both groups were treated for six months. During the treatment, all patients were followed up once a month to observe the improvement of symptoms, changes in blood pressure, blood lipid levels, ECG performance, sleep effects and the occurrence of cardiovascular accidents. Measurement data were compared using t test, count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results The total clinical effective rate was 46.5% in the control group and 94.1% in the treatment group. There was significant difference between the two groups (P <0.05). After treatment, the blood lipid level and blood pressure in the treatment group were significantly different from those in the control group (all P <0.05). The electrocardiogram and sleep quality in the treatment group were better than those in the control group (all P <0.05). Conclusion Naoxintong Capsule in elderly patients with coronary heart disease can effectively relieve symptoms, improve ECG performance and promote rehabilitation of patients with satisfactory results, and safe and reliable.