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乙酰甲胆碱或组织胺对支气管反应性的测定表明,哮喘严重程度与支气管高反应性(BHR)有关。为了探讨预防性治疗是否能减轻重症哮喘患者的BHR 的严重性,作者选择24例有严重哮喘症状者,随机分成研究组(13例)和对照组(11例),年龄19～45岁。无其它呼吸系统疾病、吸烟史和定期应用激素史,皆为特应性者。7例患过敏性鼻炎但不需经常治疗。研究组在家用气体流量计(AFM)测气道功能,每日早晚共2次,每次雾化给药前和15分钟后测气道功能,将3次数值最好的一次记录下来。AFM 记录的数值与FEV_1密切相关。所有患者大约每3个月到诊所测1次肺功能,研究组同时测支气管对组织胺的反应性。对照组症状或肺功能有改变时要
Measurement of bronchial reactivity by methacholine or histamine suggests that the severity of asthma is associated with bronchial hyperresponsiveness (BHR). To investigate whether prophylactic treatment can reduce the severity of BHR in patients with severe asthma, the authors selected 24 patients with severe asthma symptoms and were randomly assigned to study group (n = 13) and control group (n = 11), aged 19-45 years. No other respiratory diseases, smoking history and regular use of hormone history, all atopic. Seven patients had allergic rhinitis but did not need regular treatment. The research team measured the airway function in a home gas flow meter (AFM). Two times a day morning and evening, airway function was measured before and 15 minutes after the nebulization, and the best three times were recorded. The values recorded by AFM are closely related to FEV_1. All patients went to the clinic about once every 3 months for pulmonary function. The study group also tested bronchial reactivity to histamine. Control group symptoms or changes in lung function to be