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目的：观察宁夏枸杞多糖对二乙基亚硝胺诱癌作用的影响。方法：将２７只Ｗｉｓｔａｒ成年雄性大鼠分为：（１）阴性对照组，（２）阳性对照组和（３）枸杞多糖组，（２）、（３）组饮含１００ｍｇ／Ｌ浓度的二乙基亚硝胺的水溶液，（３）组每周用含１０％枸杞多糖水溶液按每次０．５ｍｌ／１００ｇ体重灌胃２次，１４周后处死大鼠，测血、肝中丙二醛、谷胱甘肽过氧化物酶及超氧化物歧化酶活性，肝脏作病检。结果：（２）、（３）组丙二醛含量明显高于（１）组（Ｐ＜０．０５）；（３）组肝内超氧化物歧化酶活性高于（２）组（Ｐ＜０．０５），谷胱甘肽过氧化物酶各组差异不明显；（１）组肝脏病变不明显，（２）组全部肝硬变（５例合并肝癌），（３）组全部肝硬变。结论：枸杞多糖通过降低丙二醛含量，增高超氧化物歧化酶活性，提高机体抗氧化物能力，从而拮抗二乙基亚硝胺的诱癌作用
Objective: To observe the effect of Ningxia wolfberry polysaccharide on the carcinogenesis of diethylnitrosamine. Methods: Twenty-seven Wistar adult male rats were divided into two groups: (1) negative control group, (2) positive control group and (3) Lycium barbarum polysaccharide group, and (2) and (3) groups of drinking water containing 100mg/L of concentration II. Ethylnitrosamine aqueous solution, group (3) weekly gavage with 10% aqueous solution of Lycium barbarum twice per 0.5ml/100g body weight, rats were sacrificed after 14 weeks, blood test, liver malondialdehyde Glutathione peroxidase and superoxide dismutase activity, liver disease. RESULTS: The malondialdehyde content in the (2) and (3) groups was significantly higher than that in the (1) group (P<0.05); (3) The activity of superoxide dismutase in the liver was higher than that in the (2) group (P< 0.05), glutathione peroxidase did not differ significantly in each group; (1) liver lesions were not obvious, (2) total cirrhosis (5 cases with liver cancer), (3) total cirrhosis change. Conclusion: LBP can antagonize the carcinogenic effect of diethylnitrosamine by decreasing the content of malondialdehyde, increasing the activity of superoxide dismutase, and increasing the antioxidant capacity of the body.