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通过放免试验或酶联免疫试验可时间一序贯性地分析Creutzfeldt-Jakob 病(CJD)患者脑脊液(CSF)中的几种神经系统特异蛋白质(Nervous sys-tem-specific protein.NS-SP)浓度。作者发现在CJD的早期阶段存在几种异常高水平的NS-SP,如神经元特异性烯醇酶(Neuron specific enolase,NSE),S-100b 蛋白,脑型肌酸激酶同功酶(CK-BB),GTP 结合蛋白G_0的α亚单位(G_0α)。一般认为在CJD 患者中,上述蛋白水平远比正常对照组和其它尚处于早期阶段的神经病患者为高。疾病活动最突出时NS-SP 达到最高水平,而终未阶段则降至正常或稍稍增高的水平。因而,NS-SP 可作为CJD 脑活动性破坏
The concentration of Nervous sys-tem-specific protein (NS-SP) in cerebrospinal fluid (CSF) of Creutzfeldt-Jakob disease (CJD) patients can be analyzed sequentially by radioimmunoassay or enzyme-linked immunosorbent assay . The authors found that there are several abnormally high levels of NS-SP in the early stages of CJD, such as neuron specific enolase (NSE), S-100b protein, and brain-type creatine kinase isoenzyme (CK- BB), and the GTP-binding protein G_0 α subunit (G_0α). It is generally believed that in CJD patients, the above protein levels are far higher than in normal controls and other neuropathies that are still in their early stages. NS-SP reached the highest level when disease activity was most prominent, but dropped to normal or slightly increased level in the final stage of disease. Thus, NS-SP can be used as brain activity disruption of CJD