目的　总结皮层下动脉硬化性脑病 (SAE)临床、CT表现及诊断要点。方法　回顾分析临床资料完整并经CT扫描的 2 80例SAE的资料。结果　长期高血压致脑内动脉粥样硬化是SAE的病理基础 ,进行性智能障碍是该病的主要临床表现 ,CT扫描显示脑内白质区多发低密度灶 ,同时合并多发腔隙性脑梗死和脑萎缩。结论　CT扫描结合临床是SAE最简便而有效的诊断手段。 Objective To summarize the clinical and CT findings and diagnosis points of subcortical arteriosclerotic encephalopathy (SAE). Methods The data of 280 cases of SAE with complete clinical data and CT scan were retrospectively analyzed. Results Long-term hypertension caused by cerebral atherosclerosis is the pathological basis of SAE. Progressive intellectual impairment is the main clinical manifestations of the disease. CT scan showed multiple low-density lesions in the white matter of the brain and multiple lacunar infarcts Brain atrophy. Conclusion CT scan combined with clinical is the most simple and effective diagnostic tool for SAE.