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癌肿病人脂蛋白代谢的变化早已报道,并建议将特定脂蛋白作为恶性肿瘤的潜在标记。Skipski从癌肿病人血清中,分离出在脂质构成和漂浮特性上类似于高密度脂蛋白(HDL)的糖基脂蛋白,称之为新蛋白质w和s(neopr-oteolipids W和s)。Wieczorek等描述了类似脂蛋白的颗粒,称之为含mRNA的脂蛋白,其某些特性类似于HDL。Mountford和Wright检测到癌肿病人的血浆脂蛋白并称之为恶性相关脂蛋白(MAL)。在这些研究中,作者分析
Changes in the metabolism of lipoproteins in cancer patients have long been reported and suggest the use of specific lipoproteins as a potential marker of malignancy. Skipski isolated glyco-lipoproteins similar to high-density lipoprotein (HDL) in lipid composition and floating properties from the serum of cancer patients called neopr-oteolipids W and s. Wieczorek et al. Described a lipoprotein-like particle called a lipoprotein containing mRNA, some of which are similar in properties to HDL. Mountford and Wright detected plasma lipoproteins in cancer patients and called them malignant-associated lipoproteins (MALs). In these studies, the authors analyze