第三军医大学大坪医院在重庆地区进行了开角性青光眼患者、相关亲属和正常人TIGR基因多态性研究,发现了编码区的突变可导致氨基酸序列、蛋白质的二级结构及等电点、抗原结合位点等发生改变,从而严重影响TIGR基因的功能,和临床青光眼发病有关。还发现TIGR基因突变与青少年开角性 Daping Hospital of the Third Military Medical University in Chongqing conducted open-angle glaucoma patients, relatives and normal TIGR gene polymorphism and found that mutations in the coding region can lead to amino acid sequence, protein secondary structure and isoelectric point, Antigen binding sites and other changes, which seriously affect the function of TIGR gene, and the incidence of clinical glaucoma. TIGR mutations were also found to be associated with open angle in adolescents