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目的分析、比较各型高白细胞性急性白血病患者临床症状和白细胞分化的免疫表型,为该疾病的诊断、预后等提供依据。方法采用流式细胞术,对高白细胞性急性淋巴细胞性白血病(HLALL)和高白细胞性急性骨髓系白血病(HLAML)(共25例)、非高白细胞性急性淋巴细胞性白血病(NHLALL)和非高白细胞性急性髓系白血病(NHLAML)(共85例)的临床表现及免疫表型做比较分析。结果与NHLA比较,HLAL发病呈现急性及髓外发展的临床特征;对白血病细胞表面免疫学标记研究发现CD13和CD33为髓系细胞较特异表型,而HLALL可以同时出现多种免疫表型。结论 HLAL发病呈现急性、髓外发展且预测性差,CD33和CD13在白细胞免疫分型的髓系细胞中为较特异标志。
Objective To analyze and compare the clinical symptoms and leukocyte differentiation phenotypes of various types of patients with acute leukemia and provide basis for the diagnosis and prognosis of the disease. Methods Flow cytometry was used to detect HL HL and HLAML (25 cases in total), non-HLBL and non-HLML The clinical manifestations and immunophenotypes of high white blood cell acute myeloid leukemia (NHLAML) (85 cases in total) were compared. Results Compared with NHLA, HLAL showed acute and extramedullary clinical features. Immunofluorescent labeling of leukemia cells showed that CD13 and CD33 were more specific phenotypes of myeloid cells, while HLALL could display multiple immunophenotypes at the same time. Conclusion The onset of HLAL is acute, with extramedullary development and poor prognosis. CD33 and CD13 are more specific markers in leukocyte immunophenotyping myeloid cells.