目的探讨胆汁ＣＥＡ对胆系良恶性病变的鉴别诊断价值。方法用放免法测定４６例胆系病人的血清及胆汁ＣＥＡ水平。结果胆石症与胆囊良性息肉胆汁及血清ＣＥＡ统计学处理无差异。胆囊癌及胆管癌胆汁ＣＥＡ分别为１２６３５±１３８６、１３４０２±１５０８明显高于其血清ＣＥＡ７７１±２９８、１３４５±３７９（Ｐ＜００１），且与胆石症及良性息肉胆汁ＣＥＡ也存在非常显著差异（Ｐ＜００１）。结论胆汁ＣＥＡ测定可为临床鉴别胆系良恶性病变，提供一个较好的辅助诊断指标 Objective To investigate the value of bile CEA in the differential diagnosis of benign and malignant biliary lesions. Methods Serum and bile CEA levels in 46 patients with biliary tract were measured by radioimmunoassay. Results There was no statistical difference between cholelithiasis and gallbladder benign polyp bile and serum CEA. The bile CEA of gallbladder carcinoma and cholangiocarcinoma were 12635±1386 and 13402±1508, respectively, which were significantly higher than those of serum CEA771±298,1345±379 (P<001). ), and CEA with gallstone disease and benign polyp bile CEA is also very significant difference (P <0  01). Conclusion Biliary CEA can provide a good auxiliary diagnostic index for the differential diagnosis of benign and malignant biliary lesions.