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目的:观察七叶皂苷钠对重型颅脑创伤患者血清神经元特异性烯醇化酶(NSE)和S-100β蛋白含量的影响。方法:48例入选患者随机分为对照组和治疗组各24例。治疗组在常规治疗基础上给予七叶皂苷钠10mg,ivd,qd,连用7d。对照组除七叶皂苷钠外其他治疗完全相同。分别在治疗前后不同时间点检测患者血清NSE和S-100β含量,3个月后行GOS评分,然后对所得资料进行统计学分析。结果:治疗后治疗组血清NSE和S-100β含量明显低于对照组(P<0.05)。治疗组GOS评分显著好于对照组(P<0.05)。结论:七叶皂苷钠能降低重型颅脑创伤患者血清NSE和S-100β含量,有改善预后的可能。
Objective: To observe the effect of sodium aescinate on serum neuron-specific enolase (NSE) and S-100β protein in patients with severe craniocerebral trauma. Methods: Forty-eight selected patients were randomly divided into control group and treatment group, 24 cases each. The treatment group was given sodium aescinate 10mg, ivd, qd on the basis of routine treatment for 7 days. The control group except for aescine sodium other treatment is identical. Serum levels of NSE and S-100β were measured at different time points before and after treatment, and GOS scores were obtained after 3 months. The data were statistically analyzed. Results: After treatment, the levels of serum NSE and S-100β in the treatment group were significantly lower than those in the control group (P <0.05). The GOS score of the treatment group was significantly better than that of the control group (P <0.05). Conclusion: Sodium aescinate can reduce the content of serum NSE and S-100β in patients with severe traumatic brain injury and improve the prognosis.