Effects of temperatures and salinities on oxygen consumption and ammonia-N excretion rate of clam Meretrix meretrix were studied in laboratory from Oct. 2003 to Jan. 2004. Two schemes were designed in incremented temperature at 10, 15, 20, 25°C at 31.5 salinity and in incremented salinity at16.0, 21.0, 26.0, 31.5, 36.0, and 41.0 at 20°C, all for 8-10 days. From 10 to 25°C, both respiration and excretion rate were increased. One-way ANOVA analysis demonstrated significant difference (P<0.01) in physiological parameters in this temperature range except between 15 and 20°C. The highest Q10 thermal coefficient value (12.27) was acquired between 10 and 15°C, and about 1 between 15 and 20°C, indicating M. meretrix could well acclimate to tem- perature changes in this range. Salinity also had significant effects on respiration and excretion rate (P<0.05). The highest values of respiration and excretion rate of M. meretrix were recorded at 16.0 salinity (20°C). These two physiological parameters decreased as salinity increased until reached the minimum Q10 value at 31.5 (20°C), then again, these parameters increased with increasing salinity from 31.5 to 41.0. M. meretrix can catabolize body protein to cope with osmotic pressure stress when environmental salinity is away from its optimal range. No significant difference was observed between 26.0 and 36.0 in salinity (P>0.05), suggesting that a best meta- bolic salinity range for this species is between 26.0 and 36.0. Effects of temperatures and salinities on oxygen consumption and ammonia-nitrogen excretion rate of clam meretrix meretrix were studied in laboratory from Oct. 2003 to Jan. 2004. Two schemes were designed in incremented temperature at 10, 15, 20, 25 ° C at 31.5 salinity and in incremented salinity at 16.0, 21.0, 26.0, 31.5, 36.0, and 41.0 at 20 ° C all for 8-10 days. From 10 to 25 ° C, both respiration and excretion rate were increased. One-way ANOVA The highest Q10 thermal coefficient value (12.27) was acquired between 10 and 15 ° C, and about 1 between 15 and 20 ° (P <0.01) in physiological parameters in this temperature range except between 15 and 20 ° C C, indicating M. meretrix could well acclimate to tem- perature changes in this range. Salinity also had significant effects on respiration and excretion rate (P <0.05). The highest values ​​of respiration and excretion rate of M. meretrix were recorded at 16.0 salinity (20 ° C). These two physiological p arameters decreased as salinity increased until reached the minimum Q10 value at 31.5 (20 ° C), then again, these parameters increased with increasing salinity from 31.5 to 41.0. M. meretrix can catabolize body protein to cope with osmotic pressure stress when environmental salinity is suggesting that the best meta-bolic salinity range for this species is between 26.0 and 36.0.