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目的:探讨系统性红斑狼疮并发低T3综合征的影响因素。方法:选择2102年6月~2013年6月于我科住院的SLE女性患者60例,其中伴有低T3综合征的30例(排除具有原发性甲状腺疾病的病例),甲状腺功能正常的30例,分析和比较伴有低T3综合征的SLE患者与甲状腺功能正常的SLE患者入院时的血常规、C反应蛋白、血沉、肝功能、肾功能、补体C3、补体C4、24小时尿蛋白等实验室指标和临床特征,并通过单因素和多因素Logistic回归分析探讨系统性红斑狼疮并发低T3综合征的影响因素。结果:伴有低T3综合征的SLE患者SLEDAI积分、红细胞计数、血红蛋白、血小板、补体C3、白蛋白、谷丙转氨酶、尿素、24小时尿蛋白定量与甲状腺功能正常的SLE患者比较均有统计学差异(P<0.05);Logistic回归分析显示SLEDAI积分(OR=2.194,1.045~4.606,P=0.038)、血红蛋白(OR=0.719,0.518~0.998,P=0.049)、谷丙转氨酶(OR=2.417,1.071~5.457,P=0.034)、白蛋白(OR=0.313,0.105~0.934,P=0.037)是系统性红斑狼疮并发低T3综合征的影响因素。结论:SLEDAI积分和谷丙转氨酶水平是系统性红斑狼疮并发低T3综合征的危险性因素,而血红蛋白和白蛋白水平是其保护性因素。
Objective: To investigate the influencing factors of systemic lupus erythematosus complicated with low T3 syndrome. Methods: Sixty women with SLE who were hospitalized in our department from June 2102 to June 2013 were selected, including 30 cases with low T3 syndrome (excluding cases with primary thyroid disease), 30 with normal thyroid function Cases, analysis and comparison of blood routine, C-reactive protein, ESR, liver function, renal function, complement C3, complement C4, 24-hour urinary protein, etc. on SLE patients with thyroid dysfunction and SLE patients with low T3 syndrome Laboratory indicators and clinical features, and single factor and multivariate Logistic regression analysis of systemic lupus erythematosus complicated by low T3 syndrome factors. Results: SLE patients with low T3 syndrome had statistically significant differences in SLEDAI score, erythrocyte count, hemoglobin, platelet count, complement C3, albumin, alanine aminotransferase, urea, 24-hour urine protein and SLE patients with normal thyroid function (OR = 2.194,1.045 ~ 4.606, P = 0.038), hemoglobin (OR = 0.719,0.518 ~ 0.998, P = 0.049) and alanine aminotransferase (OR = 2.417, 1.071 ~ 5.457, P = 0.034), albumin (OR = 0.313,0.105-0.934, P = 0.037) were the influencing factors of systemic lupus erythematosus complicated with low T3 syndrome. CONCLUSIONS: SLEDAI scores and alanine aminotransferase levels are risk factors for systemic lupus erythematosus complicated with low T3 syndrome, and hemoglobin and albumin levels are protective factors.