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目的 考察吡罗昔康凝胶的体外经皮离子导入。方法 以高分子材料制备吡罗昔康凝胶 ,大鼠皮为模型皮肤 ,采用改良Franz扩散池分别进行药物凝胶的经皮直流电导入和超音频导入 (频率为 5 0kHz ,占空比为 1∶1) ,并测定了吡罗昔康从凝胶中的释放速率。结果 与被动扩散相比 ,电流密度分别为 0 .1mA·cm-2 和 0 .2mA·cm-2 的直流电对吡罗昔康凝胶通过大鼠皮的促渗倍数分别为 2 .0 1和 3.81,对离子型药物的促渗作用较为明显 ,吡罗昔康从凝胶中呈零级释放 ,在 0 .1mA·cm-2 的超音频电流作用下 ,吡罗昔康凝胶的透皮速率和 4h累积渗透量分别为 (14.2± 4.93) μg/cm-2 ·h-1和 (32 5± 2 7.0 ) μg。 结论 电流对吡罗昔康凝胶的经皮渗透有显著的促进作用 ,相同电流密度的直流电导入和超音频导入对吡罗昔康凝胶的透皮速率和累积渗透量无显著性差异
Objective To investigate the percutaneous iontophoresis of piroxicam gel. Methods Piroxicam gel was prepared from macromolecule material. The rat skin was used as model skin. Percutaneous direct current introduction and supersonic frequency induction (frequency 50 KHz, duty ratio 1: 1 ), And the release rate of piroxicam from the gel was determined. Results Compared with passive diffusion, the current density of 0,1mA · cm-2 and 0,2mA · cm-2 of direct current on piroxican gel through the skin of rats to promote the multiples were 2.01 and 3.81, The effect of ionophore on the permeation of piroxicam was obvious. Piroxicam showed zero-order release from the gel. Under the super-audible current of 0.1mA · cm-2, the permeation rate of piroxicam and the cumulative permeation of 4h (14.2 ± 4.93) μg / cm-2 · h-1 and (32 5 ± 2 7.0) μg, respectively. Conclusions The current has a significant effect on the transdermal permeation of piroxicam gel. There is no significant difference in the transdermal rate and cumulative infiltration of piroxicam gel between the DC current with the same current density and the super audio frequency