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目的观察反复呼吸道感染(RRTI)患儿免疫指标变化,为其治疗提供理论依据。方法将2012年10月至2013年9月诊断为RRTI的62例患儿的免疫学指标水平,与同期的23例普通上呼吸道感染患儿(对照组)进行对比。结果血清IgG、IgA、CD4+/CD8+水平RRTI组低于对照组,CD8+则高于对照组,差异均有统计学意义(P<0.05,P<0.01),IgM、CD4+水平两组比较差异无统计学意义(P>0.05)。CD4+、CD8+、CD4+/CD8+、IgG、IgA、IgM指标1项以上异常者,RRTI组60例(96.8%),对照组5例(21.7%),两组比较差异有统计学意义(P<0.01)。结论 RRTI患儿存在免疫功能低下状态,可通过免疫调理提高机体免疫功能进行治疗。
Objective To observe the changes of immune index in children with recurrent respiratory tract infection (RRTI) and provide a theoretical basis for its treatment. Methods The immunological parameters of 62 children diagnosed as RRTI from October 2012 to September 2013 were compared with 23 children with common upper respiratory tract infection (control group) in the same period. Results Serum IgG, IgA and CD4 + / CD8 + levels in RRTI group were lower than those in control group, but CD8 + was higher than that in control group (P <0.05, P <0.01). There was no significant difference in IgM and CD4 + Significance (P> 0.05). 60 cases (96.8%) in RRTI group and 5 cases (21.7%) in control group had significant difference (P <0.01), and there was significant difference between the two groups ). Conclusions The children with RRTI have immunocompromised status and can be treated with immunomodulatory therapy to improve immune function.