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目的 :探讨肿瘤坏死因子 (TNFα)与肿瘤发生和转归的关系。方法 :采用酶联免疫吸附测定法检测 135例肿瘤患者TNFα水平。结果 :肿瘤患者TNFα水平为 7.5 4± 2 .70ng/ml,比正常人明显增高 (P <0 .0 1) ;肿瘤转移者为 12 .15±3.5 0ng/ml,手术切除肿瘤 2周后 ,TNFα降至 1.5 7± 0 .49ng/ml,接近正常人水平 (P >0 .0 5 )。结论 :检测肿瘤患者的TNFα水平 ,对观察肿瘤患者临床病理及疗效具有重要意义
Objective: To investigate the relationship between tumor necrosis factor (TNFα) and tumor occurrence and metastasis. Methods: Enzyme-linked immunosorbent assay was used to detect the levels of TNFα in 135 patients with cancer. Results: The level of TNFα in tumor patients was 7.5 4 ± 2. 70ng / ml, which was significantly higher than that in normal subjects (P <0.01). The tumor metastasis was 12.15 ± 3.5 0ng / ml. After 2 weeks of tumor resection, TNFα decreased to 1.57 ± 0.49ng / ml, close to the normal level (P> 0.05). Conclusion: Detecting the level of TNFα in tumor patients is of great significance for observing the clinicopathology and curative effect of cancer patients