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为了研究甲酰四氢叶酸钙使５—Ｆｕ增效对舌癌化疗的效果，作者从１９９６年开始应用甲酰四氢叶酸钙（ＣＦ—Ｃａ）使５—Ｆｕ增效对舌癌化疗共３２例。ＴＮＭ分类，Ⅰ期４例，Ⅱ期１５例，Ⅲ期１１例，Ⅳ期２例。方法：第１～５天５—Ｆｕ６００～７００ｍｇ／ｍ２。舌动脉灌注，同时ＣＦ—Ｃａ６０～７０ｍｇ／ｍ２静脉滴注；第六天水化；第七天顺铂（ＣＤＤＰ）８０～９０ｍｇ／ｍ２静脉点滴。结果：２８天评价疗效，ＣＲ６例，ＰＲ１９例，总有效率为７８％。结论：该方案疗效高，没有特别的副作用，完全适合舌癌的化疗。本文还就ＣＦ～Ｃａ使５—Ｆｕ增效的机理进行了论述。
In order to study the effects of 5-formyl-tetrahydrofolate on synergistic effects of 5-Fu on tongue cancer chemotherapy, the authors applied calcium folinate (CF-Ca) to increase the efficacy of 5-Fu on tongue cancer chemotherapy since 1996. example. The TNM classification included 4 cases of stage I, 15 cases of stage II, 11 cases of stage III, and 2 cases of stage IV. Methods: From the 1st to the 5th day, 5-Fu600-700mg/m2. Tongue artery perfusion, while CF-Ca60 ~ 70mg/m2 intravenous infusion; the sixth day of hydration; the seventh day of cisplatin (CDDP) 80 ~ 90mg/m2 intravenously. Results: Efficacy was evaluated 28 days, CR6 cases, PR19 cases, the total effective rate was 78%. Conclusion: The program has high efficacy and no special side effects. It is completely suitable for chemotherapy of tongue cancer. This paper also discusses the mechanism of the synergism of 5-Fu with CF-Ca.