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目的探讨唑来瞵酸联合局部放疗对肺癌骨转移患者的镇痛效果。方法 63例肺癌骨转移患者,给予唑来瞵酸4mg加入0·9%氯化钠注射液100ml中,静脉滴注1次/d,持续15min以上,每4周为1周期;局部放疗,DT300cGy/次,5次/周,DT总量3000cGy/10次;用药4周期及放疗DT3000cGy/10次后评价疗效。结果 63例患者中,疼痛完全缓解(CR)24例,部分缓解(PR)16例,轻微缓解(MR)12例,无缓解(MR)11例,总有效率82·5%(52/63);毒副反应主要是乏力、肌肉疼痛、恶心、呕吐、厌食、骨髓抑制等,停药或经对症治疗后恢复。结论唑来瞵酸联合局部放疗对肺癌骨转移患者镇痛效果好,且毒副反应小,可耐受。
Objective To investigate the analgesic effect of zoledronic acid combined with local radiotherapy on patients with bone metastasis of lung cancer. Methods Sixty-three patients with bone metastasis of lung cancer were treated with 4mg zoledronic acid and 100ml 0.9% sodium chloride injection once a day for 15 minutes, once every four weeks. The local radiotherapy, DT300cGy / Times, 5 times / week, DT total 3000cGy / 10 times; medication 4 cycles and radiotherapy DT3000cGy / 10 times after the evaluation of the effect. Results Among the 63 patients, there were 24 patients with complete remission (CR), 16 with partial remission (PR), 12 with mild remission (MR), and 11 without remission (MR). The total effective rate was 82.5% (52/63) ); Toxic side effects are mainly fatigue, muscle pain, nausea, vomiting, anorexia, bone marrow suppression, withdrawal or recovery after symptomatic treatment. Conclusion ZOLT combined with local radiotherapy has good analgesic effect on patients with bone metastasis of lung cancer and has little toxic side effects and is tolerable.