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目的探讨运动训练对脑出血大鼠神经功能恢复的影响。方法将90只SD大鼠随机分为运动组、对照组和假手术组,每组30只。运动组和对照组应用胶原酶诱导脑出血模型,假手术组用生理盐水替代胶原酶。运动组于术后24 h开始跑笼运动训练,每天40 min,连续1个月。分别于术后3,7,14,21及28 d对3组大鼠进行姿势反射、平衡、肌力评定。结果运动组功能恢复明显好于对照组,假手术组无明显功能障碍。结论早期运动训练有助于脑出血大鼠神经功能恢复。
Objective To investigate the effect of exercise training on the recovery of neurological function after intracerebral hemorrhage in rats. Methods Ninety SD rats were randomly divided into exercise group, control group and sham operation group, 30 rats in each group. Exercise group and control group were induced by collagenase intracerebral hemorrhage model, sham group with saline instead of collagenase. The exercise group started running cage training at 24 hours after operation for 40 min every day for 1 month. At 3, 7, 14, 21 and 28 d after operation, posture, balance and strength of the rats in each group were evaluated. Results Motor function recovery was significantly better than the control group, sham operation group without significant dysfunction. Conclusion Early exercise training can help the recovery of neurological function in rats with intracerebral hemorrhage.