1957年,瑞典开始使用脊髓灰质炎灭活疫苗(IPV),到1962年,脊髓灰质炎野毒株停止传播,从而为IPV诱生免疫力的长期随访研究提供了极好的机会。作者从1967年开始,对瑞典数百名接种IPV的儿童进行了持续18年的研究。服用的疫苗由瑞典国立细菌学实验室制备,1、2和3型病毒的比例为4:1:1,病毒采用0.0065M甲醛,30℃,35天灭活。所有儿童服用4剂疫苗。第1剂在9月龄服用、1～2个月后服第2剂,6～18个月 In 1957, Sweden began using the poliomyelitis inactivated vaccine (IPV). By 1962, the poliovirus had stopped transmitting and thus provided an excellent opportunity for long-term follow-up studies on IPV-induced immunity. From 1967, the author conducted a study of hundreds of children with IPV in Sweden for 18 years. The vaccine taken was prepared by the Swedish National Bacteriological Laboratory with a ratio of 4: 1: 1 viruses of type 1, 2 and 3, 0.0065M formaldehyde of viruses and inactivated 35 days at 30 ° C. All children take 4 doses of vaccine. The first dose at 9 months of age, 1 to 2 months after taking the second dose, 6 to 18 months