米索前列醇用于晚期妊娠引产正被广泛用于临床。一般采用阴道后穹窿给药或口服给药。因药物首过效应口服给药效果次于阴道后穹窿给药,对胎膜早破阴道给药易诱发感染或药物易诱发染或药物被羊水溶解,部分排出体外而影响疗效。近期对胎膜早破采用米索直肠给药,效果满意,现报告如下:1.资料与方法1·1 临床资料: 自1998年5月至1999年5月,我院对50例37 Misoprostol for late pregnancy induction is widely used in clinical practice. Vaginal posterior fornix administration or oral administration. Due to the first-pass effect of oral drug administration after vaginal posterior fornix administration, vaginal premature rupture of membranes to induce infection or drug-induced dye or drug dissolved in amniotic fluid, partially excreted and affect the efficacy. Recent premature rupture of membranes with misoprostol rectal administration, the results are satisfactory, are as follows: 1. Materials and methods 1.1 Clinical data: from May 1998 to May 1999, our hospital for 50 cases of 37