已经证明某些抗生素的亚-MIC对细菌的形态学及超微结构的特征有修饰作用。药物接触细菌,如用氯林霉素和单环β-内酰胺类抗生素的亚-MIC处理细菌,就可以导致多形核白细胞吞噬作用的增强。第四代头孢菌素Cefepime(BMY28142)对革兰氏阳性阴性菌具广谱抗菌作用。已有报道Cefepime对青霉素结合蛋白(PBP_s)2和3能发挥这种作用。PBP_s是肽聚糖生物合成最后阶段的催化酶,而由于它可导致细胞表层结构缺损,合成异常的肽聚糖,产生了PBP_s的抑制作用,这在宿主防御和细菌之间的相互作用方面,可能有着重要影响。作者用Cefepime的亚-MIC与革兰氏阴 Sub-MICs of certain antibiotics have been shown to modify bacterial morphological and ultrastructural features. Drug exposure to bacteria such as bacteria treated with subclinical clindamycin and monocyclic β-lactam antibiotics can result in enhanced phagocytosis of polymorphonuclear leukocytes. Fourth-generation cephalosporin Cefepime (BMY28142) against Gram-negative bacteria with broad-spectrum antibacterial effect. Cefepime has been reported to exert this effect on penicillin-binding proteins (PBP_s) 2 and 3. PBP_s is the catalytic enzyme in the final stage of peptidoglycan biosynthesis, and because it can cause cell surface structural defects, the synthesis of abnormal peptidoglycan, the inhibition of PBP_s, which in the host defense and the interaction between bacteria, May have a significant impact. The authors used Cefepime’s sub-MIC with Gram-negative